Moreover, some measures, i.e., the longitudinal peak systolic velocity,correlate with brain-type natriuretic peptide (BNP) levels better than EF [23].Considering TDI measures, longitudinal peak velocities are reduced in aorticstenosis, aortic regurgitation and mitral regurgitation despite the preserved EF[24, 25, 26]. This evidence concerns the gene NPPB and mitral valve insufficiency.