Nonetheless,alleviated TGF-β and collagen gene expression in treated animals mightreflect that exercise training may mitigate fibrosis in cardiac tissue byinhibiting the molecular mechanism such as renin-angiotensin-aldosterone-systemthat leads to the prevention of myocardial collagen deposition and consequentlycardiomyopathy in diabetes [4, 6]. This evidence concerns the gene TGFB1 and diabetes mellitus.