PPARGC1A and familial dilated cardiomyopathy: Meanwhile, theexpression was higher in the combined group of Met-HIIT.PGC-1α, as a primary modifier in the biogenesis ofmitochondria, has a potential role in the energy metabolism of the myocardium.The researchers indicated that exercise training improves DCM throughameliorating cardiac performance associated with restoring mitochondrialbiogenesis, accompanied by PGC-1α activation and Akt signaling[19].