Notably, lifestyle changes [37, 38] andmajor anti-HTN drugs, including diuretics [39], renin-angiotensin-aldosteronesystem (RAAS) inhibitors [40, 41, 42], angiotensin–neprilysin inhibitors [43],calcium channel blockers (CCBs) [44], and beta-blockers [45, 46], can prevent andreverse HTN-induced LVH. This evidence concerns the gene REN and hypertensive disorder.