Secreted frizzled-related protein 2 (sFRP2), a vital modulator in Wnt signaling,plays an important role in cardiac remodeling caused by hypoxia [8, 9, 10],hypoxia-reoxygenation (HR) [11], pressure overload [12], and autoimmunemyocarditis [13] through regulating cardiac fibrosis, hypertrophy, cell death,and regeneration. This evidence concerns the gene SFRP2 and fibrosis.