After adjusted for age and gender, hypertension (OR = 2.438, 95%CI: 1.647–3.609, p< 0.001), diabetes (OR = 2.344, 95% CI:1.624–3.383, p< 0.001), smoking (OR = 1.890, 95% CI: 1.087–3.287,p = 0.024), clopidogrel (OR = 1.464, 95% CI: 1.013–2.114, p =0.042), FBG (OR = 1.167, 95% CI: 1.075–1.268, p< 0.001), HbA1c (OR= 1.274, 95% CI: 1.108–1.464, p< 0.001), and IL-2R levels (OR =1.001, 95% CI: 1.001–1.003, p< 0.001) still correlated with severeCAC (Model 2). Here, IL2RA is linked to Hypertension.