In astudy including 26,025 participants, compared with a reference group with LDL-C<130 mg/dL and no mutation, there was a 6-fold higher risk for CAD inparticipants with LDL-C ≥190 mg/dL and no FH mutation and a 22-fold higherrisk in those with both LDL-C ≥190 mg/dL and an FH mutation [34].Similarly, a study including 409 FH patients participating in the Simon BroomeBritish Heart Foundation study showed that compared with those with no mutation,the participants with LDLR mutation had 70% higher odds of CAD, andthose with PCSK9 mutation had 20-fold higher odds of CAD [35]. The gene discussed is LDLR; the disease is coronary artery disorder.