EDN1 and cardiovascular disorder: Then, in response, they can producea variety of endogenous vasoactive factors such as nitric oxide (NO),prostacyclin, endothelin-1 (ET-1), and vascular cell adhesion molecule-1(VACM-1), all of which are involved in the regulation of vascular tone,inflammatory response, oxidative stress, and other endothelial functions [1, 2, 3].Studies have revealed that normal arterial endothelial function is essential formaintaining vascular health, while impaired endothelial function constitutes theinitiating factor in the development and progression of cardiovascular diseases[4, 5].