In thePRIDE study, patients with HF had higher levels of galectin-3 compared with thosewithout, but for the diagnosis of HF, NT-proBNP outperformed galectin-3 [73].Galectin-3 may have a prognostic role in predicting long-term mortality inpatients with acute HF, as described by Lala et al. [74], where patientswith high baseline galectin-3 values ​​(>16.5 ng/mL) had a significantly worsesurvival profile over the 18-month follow-up for all-cause mortality. The gene discussed is NPPB; the disease is hydrops fetalis.