Other factors may causechanges in the levels of NPs in addition to kidney disease, neprilysin inhibitors(in the latter case except, as already mentioned, for NT-proBNP) — (Table 1).Increases in NT-proBNP could also identify patients most at risk of suddencardiac deaths in the preclinical phase of HF, as demonstrated by prospectivedesign studies [37]. Here, NPPB is linked to kidney disorder.