Similarly, severe MR was related to lower LVEF (29.5% [IQR = 27%–33%] vs 30% [IQR = 26%–34%], p = 0.01) and greater LVEDD (71 [IQR = 65–73] mm vs 66 [IQR = 59–72] mm, p < 0.001) among those with higher ePASP, but there was no substantial difference in NT-proBNP between non-severe and severe MR groups (logarithmic form: 8.43 [IQR = 8–9] vs 7.96 [IQR = 7–9], p = 0.18) (Fig. 3). The gene discussed is NPPB; the disease is miotic rate.