Breast cancer is the most frequently diagnosed cancer in the United States (US)and worldwide with an increasing incidence rate of 0.5% each year [1, 2].Hormone receptor-positive and human epidermal growth factor receptor type 2negative (HR+/HER2–) is the most common subtype, with an approximate five-yearsurvival rate of 90%. Here, ERBB2 is linked to breast carcinoma.