IL1B and diabetes mellitus: CAD and DM involve complex physiological processes, and chronic inflammation hasbeen widely accepted as the pathological mechanism for these two diseases [9].CAD is essentially an inflammatory disease, risk factors such as dyslipidemia,hyperglycemia, smoking, and hypertension induce endothelial cell damage,stimulate immune cell proliferation, resulting in the upregulate of theexpression of inflammatory and procoagulant cytokines such as IL-1β andFIB [31, 32, 33, 34], ultimately leading to CAD.