Patients with MACCEs wereassociated with increased odds of heart failure (HR [hazard ratio] 1.270, 95%CI: 1.029–1.567), insulin use (HR 1.263, 95% CI: 1.023–1.559),sodium-dependent glucose transporters 2 (SGLT2) use (HR 1.799, 95% CI:1.258–2.574), HbA1c (HR 1.069, 95% CI: 1.011–1.131), lymphocytes (HR 1.012,95% CI: 1.002–1.022), Gensini score (HR 1.014, 95% CI: 1.011–1.017), highGensini score (Gensini score >74.8605) (HR 2.171, 95% CI: 1.741–2.707) andNT-proBNP (HR 1.000, 95% CI: 1.000–1.000). This evidence concerns the gene INS and heart failure.