IRS1 and dental caries: The following keywords (alone and/or incombination) were used: preschool, children, sugar intake, cardiometabolic,dental caries, genetics, heritability, single nucleotide polymorphism, solutecarrier family 2 member 2 (SLC2A2) , dopamine receptor D2(DRD2), taste 1 receptor member 2 (TAS1R2), taste 1 receptormember 3 (TAS1R3), G protein subunit alpha transducin 3(GNAT3), cannabinoid receptor 1 (CNR1), proprotein convertasesubtilisin/kexin type 1 (PCSK1), insulin receptor (INSR),insulin receptor substrate 1 (IRS-1), and insulin receptor substrate 2(IRS-2).