In particular, in the logit-matched cohort,age [HR: 0.976; 95% CI: 0.956–0.997; p = 0.022], LA diameter [HR:1.050; 95% CI: 1.004–1.097; p = 0.032] and log (NT-pro-BNP) [HR:4.338; 95% CI: 2.137–8.804; p< 0.001] were risk factors for SCD. Here, NPPB is linked to Schnyder corneal dystrophy.