A miRNA-497-5p antagomir (inhibitor) could mimic thebenefits of exercise on MI, including reduced infarct size and improved cardiacfunction, whereas miRNA-497-5p agomir aggravated the infarct size post-MI andabrogated the positive effects of ET maybe through its target chloridevoltage-gated channel 3 (CLCN3) [47]. The gene discussed is CLCN3; the disease is myocardial infarction.