A significant reduction of miR-126-3p expressionwas associated with the downregulation of RAF1 (raf-1 proto-oncogene, serine/threonine kinase), vascular endothelial growth factor (VEGF), and phosphoinositide 3-kinase (PI3K), high bloodglucose level, insulin resistance, and angiogenesis impairment in diabetes, allof which could be reversed by exercise. This evidence concerns the gene RAF1 and diabetes mellitus.