HMGCR and Disorder of lipid metabolism: miR-21a-5pdownregulation was associated with the occurrence and progression ofhyperlipidemia, caused lipid metabolism disorder and overexpression of targetgenes such as, fatty acid binding protein 7 (FABP7),3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), acetyl-CoA acetyltransferase 1(ACAT1), and oxidized low-density lipoprotein receptor 1(OLR1).