Correspondingly, GLUT-4-mediated glucose uptake intosubcutaneous adipocytes is markedly reduced in patients with insulin resistance(including T2D), suggesting that defective glucose uptake into subcutaneousadipocytes contributes to cause whole-body insulin resistance [276, 277, 278, 279, 280, 281, 282, 283]. This evidence concerns the gene SLC2A4 and type 2 diabetes mellitus.