MMP2 and chronic kidney disease: Furthermore, an abnormal composition of extracellular matrix,which is observed in CKD patients where it associates with abnormal serum levelsof matrix metalloproteinases (e.g., matrix metalloproteinases 2, matrix metalloproteinases 7 (MMP-2, MMP-7)), may contribute to acceleratedplaque rupture and the onset of acute cardiac events [30].