In a cohort of 8622 participants(of which 10.9% had eGFR <60 mL/min or albumin-creatinine ratio (ACR) >30 mg/g) during a follow-up of11.9 years, the overall incidence rate of CV events was 38.0 per 1000person-years in CKD patients (16.0 per 1000 person-years in non-CKD); thisfinding was strongly associated with the values of beta2-microglobulin,Troponin-T and pro B-type natriuretic peptide (pro-BNP) with HR 1.22 (95% CI 1.16–1.29), 1.61 (95% CI1.43–1.81) and 1.50 (95% CI 1.34–1.68) respectively [62, 63, 64]. Here, ALB is linked to chronic kidney disease.