In addition, CPS1-IT wasfound to be downregulated and IL-1β was found to be upregulated in thepulmonary artery tissue of obstructive sleep apnea (OSA) model rats.Overexpression of CPS1-IT reduces IL-1β expression by inhibiting thetranscriptional activity of HIF1, thereby inhibiting the NF-κB signalingpathway. This evidence concerns the gene NFKB1 and obstructive sleep apnea syndrome.