For example, in the ToR–ORd model, the hypernatremia induces an increasein [Na+]i from its baseline value of 12.6 mmol/L to 24.7 mmol/L in thepresence of the ion current scaling, which is a substantially smaller increase to17.7 mmol/L in the absence of the ion current scaling (Fig. 10J). This evidence concerns the gene RORC and Hypernatremia.