Serum IGF-1 levels are preferred over GH levelsas biomarker the in the diagnosis of acromegaly due to several factors:significantly longer half-life of approximately 15 hours compared to less than anhour for GH, the episodic nature of GH secretion, and a closer correlation ofIGF-1 levels with the onset of clinical signs, wherein an elevated IGF-1 withnormal GH reflects an earlier stage of the disease [9]. The gene discussed is GH1; the disease is acromegaly.