In a cohort study by Wuet al. [21] in 2020, 1195 patients displayed excessive risk of mortality(41% more) over a 17-year period, with higher risk in early-onset disease.Excessive circulating GH and IGF-1 in acromegalic patients induce comorbiditiessuch as CVD (atherosclerosis, cardiomyopathy, arrythmias), diabetes, and cancers(digestive, respiratory, breast and lymphoma), which are direct contributors ofhigher mortality in acromegaly patients [21]. The gene discussed is IGF1; the disease is acromegaly.