ZFHX3 and atrial fibrillation: Thus, the impact of the SNP rs2106261 on postablation AF is also controversial.rs2106261 is located within the intron of the ZFHX3 gene, which encodes ZFHX3 ((orAT motif binding factor 1, (ATBF1)), a transcription factor containing multiplehomologous structures and zinc finger motifs [44].