In contrast, Shim et al. [23] founda higher rate of early recurrence in patients containing the rs1799983 variant;this may be due to reduce NO activity leading to slower inflammatory regressionafter atrial fibrillation ablation (RFCA), thus promoting recurrence of AF.Second, dysfunction of NOS and NO in atrial oxidative damage and electricalremodeling may also contribute to the reproduction of AF. The gene discussed is NOS1; the disease is atrial fibrillation.