It was determined that carriers of the TT ApaI, TC TaqI, and GA BsmIgenotypes exhibited higher risk for obesity, whereas the FokI TT genotype waslinked to an increase in the occurrence of heart failure and hypertension [71].These investigators suggested that specific VDR genotypes are associated withcirculating levels of 25-OH vitamin D. Taken together, low 25-OH vitamin D3 maybe associated with a higher risk of diabetes and obesity and subsequent heartfailure [72]. The gene discussed is VDR; the disease is obesity due to melanocortin 4 receptor deficiency.