Indeed, areduction in PKC α levels has been shown to be linked to an attenuationof the cardiac hypertrophic markers, brain natriuretic peptide (BNP) and atrialnatriuretic factor (ANF) and improved cardiac function, in the same model,suggesting that vitamin D deficiency may be related to cardiac hypertrophy [37]. The gene discussed is NPPB; the disease is vitamin D deficiency.