Animal studies in the low-dosestreptozotocin-induced diabetic rat show that markers of diabetic cardiomyopathywere markedly ameliorated following insulin replacement indicating that insulinreplacement can reduce complications of diabetes including cardiomyopathy [41].Therefore, our research provides a little support for clinical prevention ofdiabetic cardiomyopathy. This evidence concerns the gene INS and cardiomyopathy.