Adding log RBP4 to a basic riskmodel including age, BMI, diabetes duration, LVEF, insulin treatment, TG, LDL-C,eGFR, CRP, log NT-proBNP, retinopathy, nephropathy and neuropathy improved thec-index from 0.91 to 0.94 (p = 0.024) (Table 3). The gene discussed is CRP; the disease is retinal disorder.