After myocardial infarction, poorly adapted left ventricular remodeling couldoccur due to impaired angiogenesis, which can further promote transition fromadaptive myocardial hypertrophy to left ventricular dilation and dysfunction.Exercise training has been demonstrated to activate VEGF dependent angiogenesispathways and increase VEGF expression in the heart [134, 135, 136, 137]. The gene discussed is VEGFA; the disease is cardiac hypertrophy.