In our study, we observed an increased expression ofUCP2 and Nrf2, as well as the antioxidants (SOD-2, HO-1) in the hearts of WT micepost CKD exposure, while ALDH2 deficiency significantly reduced the expressionsof UCP2, Nrf2, SOD-2, and HO-1. The gene discussed is SOD2; the disease is chronic kidney disease.