SPG11 and amyotrophic lateral sclerosis: For example, SPG11 and KIF5A have been found to be pathogenic in both ALS and SPG (Stevanin et al., 2007; Orlacchio et al., 2010; Nicolas et al., 2018), and SPTLC1 has been recognized as a novel risk gene factor in ALS and HSAN2 (Lone et al., 2022).