In addition, 14 ALS patients with KIF1A mutation did not cover other ALS-related genes, including SOD1, SETX, FUS, ALS2, OPTN, TARDBP, DCTN1, VAPB, Fig 4, TBK1, CHCHD10, ANXA11, NEK1, SQSTM1, and C9orf72, which were classical pathogenic genes in ALS, by WES analysis. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.