For example, numerous genes associated with ALS, including DCTN1, KIF5A, ALS2, NEFH, PFN1, and SPAST, participate in controlling cytoskeletal dynamics and function and regulate intracellular transport events (Liu et al., 2017; Nicolas et al., 2018; Castellanos-Montiel et al., 2020). Here, ALS2 is linked to amyotrophic lateral sclerosis.