Multivariate analysis revealed that increased level of TLR4 at 0-hour upon ICUadmission was identified as a risk factor for developing postoperative AKI (OR3.046, 95% CI 1.435–7.024; p = 0.006) and increased 30-day mortality(OR 2.604, 95% CI 1.039–6.002; p = 0.016). Here, TLR4 is linked to acute kidney injury.