Aprevious study showed that TLR4 expression was upregulated in acisplatin-mediated AKI model [6], cyclosporin induced nephrotoxicity [7], lupusnephritis [8], unilateral ureter obstruction [9], diabetic nephropathy [10], andrhabdomyolysis-induced AKI [11]. The gene discussed is TLR4; the disease is acute kidney injury.