CRPpromotes vascular remodeling and pulmonary endothelial dysfunction by enhancingthe pulmonary arterial smooth vascular cell mitogenic activity and monocyteadhesion to pulmonary arterial endothelial cells, endothelin(ET)-1, and von Willebrand factor (vWF) secretion among CTEPH patients [28]. This evidence concerns the gene VWF and chronic thromboembolic pulmonary hypertension.