Each 1 mmol/L decrease in LDL-C level was associated with a significantreduction of all stroke risk by 23.5% (slope = 0.235; [95% CI: 0.007–0.464]).PCSK9 inhibitors are proven to have the greatest ability to reduce stroke ratesamong various lipid-lowering drugs [70]. The gene discussed is PCSK9; the disease is stroke disorder.