Second, PCSK9 inhibitors havebeen shown in large RCTs not to induce NODM, HS, cognitive effects, andcataracts, and do not have DDIs with anti-HIV drugs [21, 47, 48, 66, 74, 109].Hence, PCSK9 inhibitors are a safe alternative in the above conditions.Nevertheless, due to the mild degree of statin-induced AEs, statin use is notstrictly limited in patients at risk for NODM, cognitive impairment, andcataracts [18, 45, 71]. Here, PCSK9 is linked to Cognitive impairment.