This maybe due to the mechanism of SGLT2i on the cardiovascular system.First, the benefit of SGLT2 inhibitors may be due to long-termchanges in tissue sodium management after the initial diuresis, which lowersblood pressure, reduces ventricular afterload and reverses remodeling [27].Second, overactivity of the sympathetic nervous system is another important causeof heart failure progression, and SGLT2i could reduce cardiac sympatheticactivity [28]. This evidence concerns the gene SLC5A2 and heart failure.