[20] recently found that the expression of IL-1R2 in AMI patients was higherthan that in healthy controls, and a three-gene signature comprising IL1R2, C-Cmotif chemokine ligand 20 (CCL20), and Intelectin-1 (ITLN1) exhibited outstandingperformance in MI diagnosis. The gene discussed is IL1R2; the disease is myocardial infarction.