In a previous study, IL-1R2 expression was reduced in monocytesfrom hyperlipidemic patients and in human atherosclerotic lesions, suggesting apotential role for low IL-1R2 expression in atherosclerosis progression [23].Although myocardial damage and infarction size are the major determinants of leftventricular remodeling and impaired recovery of LV function, excessive local andsystemic inflammation may accelerate this process. The gene discussed is IL1R2; the disease is atherosclerosis.