CPLANE1 and keratoconus: Differentially expressed genes (DEGs) according to high-throughput RNA-sequencing data of keratoconus (GSE77938) showed that the level of CPLANE1 gene expression was upregulated in the corneal tissues of keratoconus patients (experimental group) compared with the normal control group, logFC = 0.62720952, and the difference was statistically significant (p = 0.000515, <0.05) (Figure 4C).