CREB is phosphorylated at Ser133 by various receptor‐activated protein kinases, such as protein kinase A, mitogen‐activated protein kinases, and CaMK.[21, 22] It remains unknown whether CaMKK2‐induced CaMK4 phosphorylates Ser133 or other CREB sites in lung cancer. The gene discussed is CREB1; the disease is lung cancer.