CREB is phosphorylated at Ser133 by various receptor‐activated protein kinases, such as protein kinase A, mitogen‐activated protein kinases, and CaMK.[21, 22] It remains unknown whether CaMKK2‐induced CaMK4 phosphorylates Ser133 or other CREB sites in lung cancer. Here, CAMK4 is linked to lung carcinoma.