Considering the severe downregulation of several genes in the prolactin family in E10.5 PCOS‐mice placenta (Figure 3f), we next explored whether prolactin supplement could prevent the adverse effects induced by androgen exposure, given its previously demonstrated role in enhancing differentiation and invasion of human trophoblast cells.[52] The prolactin experiment consisted of the following groups: control (CNT group), 100 ng mL−1 prolactin (PRL group), 1 nm DHT (DHT group), 1 nm DHT + 100 ng mL−1 prolactin (DHT + PRL group). The gene discussed is PRL; the disease is polycystic ovary syndrome.