HMGCS2 and polycystic ovary syndrome: Nonetheless, the protein−lipid complex remodeling pathway was downregulated in PCOS‐mice placentas (Figure 2d).[29] Specifically, Hmgcs2, encoding HMG‐CoA synthase, involved in a metabolic pathway providing lipid‐derived energy,[31] exhibited a four‐fold increase in expression in PCOS‐mice compared to controls (Figure 2e).