While a few Treg associated biomarkers including IL-10, IL-2R and CCL17 were found to be elevated in PV patients compared to healthy controls, c-c chemokine receptor (CCR)4, Treg cell count and the forkhead box protein (FOXP)3 transcription factor unique to Treg cells were found to be decreased. The gene discussed is FOXP3; the disease is acquired polycythemia vera.