TNF and obesity due to melanocortin 4 receptor deficiency: (2) Adipose tissue might effectively diminish the levels of potentially detrimental factors like TNF-α, thereby mitigating their impact in patients with CCI [40]; (3) It has been suggested by some researchers that due to the general medical perception associating obesity with adverse outcomes, obese patients with CCI might receive more intensive treatment, ultimately resulting in improved prognoses [22].