However, the ITGB3+ population only increased within mesenchymal EpCAMneg and full mesenchymal cancer cells (Fig. 1G), suggesting that the enrichment of ITGB3+ cancer cells in mixed cSCCs is a consequence of the emergence of EpCAMneg cancer cells in these tumors (Fig. 1E). The gene discussed is ITGB3; the disease is cancer.