IGF1R and cancer: Accordingly, the abrogation of IGF1R signaling reduced the response of epithelial plastic cancer cells to TGFβ1, blocking the generation of mesenchymal cancer cells and the upregulation of EMT-TFs, even though canonical and non-canonical TGFβ signaling did not appear to be altered upon IGF1R inhibition (Fig. 5K-L, S5I-S5J, and S6A-C).