TP53 and intrahepatic cholangiocarcinoma: The ICC divides the hypodiploid B-ALL/LBL into two subtypes, a low hypodiploid one (32–39 chromosomes), more common in adults, and a near haploid one (24–31 chromosomes), more common in children and associated with poor prognosis and, frequently, with Li-Fraumeni syndrome (germline TP53 mutation).