One subcategory of WHO-HAEM5 AML defined by differentiation, acute erythroid leukemia (AEL, previously termed ‘pure erythroid leukemia in WHO-HAEM4R), nearly ubiquitously harbors bi-allelic TP53 mutations and complex karyotype and thus corresponds to AML with mutated TP53 in the ICC. The gene discussed is TP53; the disease is acute myeloid leukemia.