In laryngeal squamous cell carcinoma (LSCC), Cao et al. observed that circMMP9, with elevated expression, could secure its expression through IGF2BP2 binding in an m6A-dependent manner and promote TRIM59 transcription by ETS1 recruitment, activating the PI3K/AKT signaling pathway and promoting LSCC progression [84]. This evidence concerns the gene IGF2BP2 and laryngeal squamous cell carcinoma.