Conversely, m6A-modified circFUT8, regulated by YTHDF2 can not only competitively interacte with YTHDF2 and blunt its binding to mFUT8, but also bind to miR-186-5p to enhance the stability of mFUT8, thereby promoting the malignancy in lung adenocarcinoma (LUAD) [86]. This evidence concerns the gene YTHDF2 and lung adenocarcinoma.