Similarly, m6A-modified circAFF2 and circ_0003215 can also be degraded by YTHDF2, while circAFF2 inhibits the neddylation modification of CRC cells and enhances the radiosensitivity of CRC by facilitating the interaction of CAND1 with Cullin 1 [112]. Here, CAND1 is linked to colorectal carcinoma.