To validate the expression patterns of vital prognostic PMRGs, we leveraged the TISCH database to scrutinize HSD17B1 expression in both BLCA and pan-cancer contexts, as illustrated in Fig. S5G and I. Analysis using the KM plotter dataset unveiled an association between high HSD17B1 expression and poorer patient prognosis (Fig. S5H). Here, HSD17B1 is linked to bladder transitional cell carcinoma.