A previous study also shows that icariin can suppress the M2 phenotype polarization of Raw264.7-derived TAMs and attenuate their CCL5 expression by inhibiting SPI1, thereby suppressing osteoclast differentiation in the presence of the conditioned medium of tumor-associated macrophages and diminishing prostate cancer metastasis-induced bone destruction [51]. This evidence concerns the gene CCL5 and Familial prostate cancer.