HAVCR2 and cancer: Here, we found that TREM2 was significantly positively correlated with HAVCR2 gene encoding TIM-3 (Fig. 3E), which was identified as a potential candidate for cancer immunotherapy due to its roles in mediating the effective termination of Th1 cells, inducing the exhaustion of T cells and enhancing the immunosuppressive function of Treg cells [37–40].