Previous studies have reported that the rare T cell infiltration is one of the critical reasons for immunosuppressive GBM microenvironment, and the infiltrated T cells are mainly Th2 cells and Treg cells which promote GBM growth [15, 30, 31], so we then investigated whether the improved therapeutic outcomes of GBM with TREM2 inhibition was related to the changes of T cell infiltration and differentiation. Here, TREM2 is linked to glioblastoma.