In this study, we discovered that the Dq values of GBMTREM2−KD cells, which represented the ability of cells to repair sub-lethal damage, were lower than corresponding GBM-NC cells (Table S3), and TREM2 silencing decreased the expression of DNA-PKcs, KU70 and KU80 in GBM cells (Fig. 2H), suggesting TREM2 inhibition significantly and directly enhanced the radiosensitivity of GBM through interfering with DNA double strand break repair pathway. The gene discussed is XRCC5; the disease is glioblastoma.