The results indicated that, A2-CM-NP/siTREM2/spam1 dramatically inhibited the recruitment of Th2 cells (GATA3+) and promoted the homing of Th1 cells (T-bet+), while radiotherapy significantly increased the number of Th2 cells and decreased the number of Th1 cells infiltrated in GBM microenvironment (Figs. 7D, E and S3). Here, TBX21 is linked to glioblastoma.