SPAM1 and glioblastoma: In order to responsively release and efficiently concentrate the loaded siTREM2 in GBM region, GBM CM-biomimetic, GSH-responsive, A2-modificatory NPs named A2-CM-NP/siTREM2/spam1 were designed and synthesized according to the synthesis process shown in Fig. 5A, and the co-loaded spam1 plasmid could express hyaluronidase to degrade extracellular matrix.