XRCC6 and glioblastoma: In this study, we discovered that the Dq values of GBMTREM2−KD cells, which represented the ability of cells to repair sub-lethal damage, were lower than corresponding GBM-NC cells (Table S3), and TREM2 silencing decreased the expression of DNA-PKcs, KU70 and KU80 in GBM cells (Fig. 2H), suggesting TREM2 inhibition significantly and directly enhanced the radiosensitivity of GBM through interfering with DNA double strand break repair pathway.