NFIX and scoliosis: Based on the present data and previous experience in the pediatric population, individuals with overgrowth and moderate to severe ID, slender habitus with or without low BMI, ophthalmologic issues, musculoskeletal problems (mainly scoliosis) and psychobehavioral issues strongly impacting QoL should be mainly addressed towards a clinical diagnosis of MALNS with respect to SS, although a molecular confirmation through whole exome sequencing or an overgrowth multigene panel including NFIX, NSD1 and other genes of interest in differential diagnosis is highly recommended.