TP53 and neoplasm: The dysregulated metabolism observed in rapidly proliferating tumor cells is a hallmark of malignancy [32], contributing to the activation of various metabolism-related genes, including several hypoxia-related transcription factors like hypoxia-inducible factor (HIF), nuclear factor kappa-B, CREB, AP-1, p53, Sp1/3, Egr-1, and CEBPB [33].