[38] In this study, 11 cytokines were elevated in metastatic melanoma patients with severe irAEs: Fractalkine, fibroblast growth factor 2 (FGF-2), interferon alpha 2 (IFN-α2), IL-12p70, IL-1a, IL-1B, IL-1RA, IL-2, and IL-13, granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF). This evidence concerns the gene IFNA2 and metastatic melanoma.