In univariate analyses, per 1-SD increments of TC, TG, ApoA1, ApoB, LDL-c, triglyceride glucose index, TG/HDL-c, and TC/HDL-c in early gestation were positively associated with the risk of GDM, except for per 1-SD increments of HDL-c, which were negatively associated with the risk of GDM (P < 0.05, Table 2). The gene discussed is APOA1; the disease is gestational diabetes.