Previous studies have shown that downregulation of ICAM2 was correlated with poor prognosis in certain cancers (breast, lung, bladder, and soft tissue cancers) [23], and SERPINC1 expression was positively correlated with overall survival, progression-free survival, relapse-free survival, and disease-free survival of HCC patients [24]. This evidence concerns the gene ICAM2 and hepatocellular carcinoma.