TNF and type 2 diabetes mellitus: An increasing amount of research indicated that inflammation was a major factor in the etiology of type 2 diabetes [7].An essential insulin signaling pathway intermediary called Akt was inactivated as a result of the stimulation of the C-Jun N-terminal kinase (JNK) signaling pathway by tumor necrosis factor (TNF-) and interleukin 1 (IL-1) [8].TNF- may also activate nuclear factor kappa B (NF-B), a transcription factor that stimulates the production of numerous inflammatory cytokines that can result in insulin resistance, by activating the IB kinase (IKK) pathway [9].