The prevalence of Type 2 Diabetes was found to be correlated with higher levels of immunoglobulin A (IgA) and lower levels of immunoglobulin M (IgM) and IgG in a cross-sectional study [18].However, since exposure and disease are only evaluated at a single time point, it is hard to identify any causality between the two in any cross-sectional study [19].The study aimed to explore whether immunoglobulin levels in a general population were associated with the risk of developing Type 2 Diabetes, hence suggesting a basis for any potential disease prevention. This evidence concerns the gene CD40LG and type 2 diabetes mellitus.