For instance, CRISPR-Cas9 gene KO of long non-coding RNA UCA1 in ovarian cancer cells exhibited some positive effects in eliminating cancer cell proliferation and elevating the apoptosis through upregulating FAS, BAK, BAX, and P53 genes and downregulating BCL-2 and SURVIVIN genes (Montazeri-Najafabadi et al. 2022). Here, TP53 is linked to cancer.