RIPK3 and acute myeloid leukemia: For instance, downregulation of RIPK3 has been reported in acute myeloid leukemia (AML) (Höckendorf et al. 2016), colorectal cancer (Feng et al. 2015), breast cancer (Stoll et al. 2017; Koo et al. 2015), and melanoma patients (Höckendorf et al. 2016).