Remarkably, upregulation of IMPDH2, which often triggers its polymerization, is reported in Alzheimer’s diseases postmortem tissue and mouse models (Neuner et al, 2017; Puthiyedth et al, 2016; Xu et al, 2019), suggesting a broader implication of IMPDH2 polymerization in neurodegeneration. Here, IMPDH2 is linked to Alzheimer disease.