MUC16 and neoplasm: Additionally, the three patients without CA125 response, but with RECIST response did not achieve long-term responses: one patient had PR on the first staging scans at 2 months, then PD on the subsequent scans at 4 months, one patient also had PR on the first staging scans, then PD at 6 months, and one patient had PR but withdrew consent prior to cycle 4 despite improvement in tumor size (Fig. 2f).